• Vertex Pharmaceuticals average pre-tax profit margin for 2023 was 44.91%, a 1.61% decline from 2022.
• Vertex Pharmaceuticals average pre-tax profit margin for 2022 was 44.2%, a 9.22% increase from 2021.
• Vertex Pharmaceuticals average pre-tax profit margin for 2021 was 40.47%, a 8.04% increase from 2020.

Pre-tax profit margin can be defined as earnings before taxes as a portion of total revenue.