• Vertex Pharmaceuticals average operating margin for 2023 was 41.16%, a 9.42% decline from 2022.
• Vertex Pharmaceuticals average operating margin for 2022 was 45.44%, a 17.23% decline from 2021.
• Vertex Pharmaceuticals average operating margin for 2021 was 38.76%, a 4.95% increase from 2020.

Operating margin can be defined as operating margin measurement of what proportion of a company's revenue is left over after paying for variable costs of production such as wages, raw materials, etc.