• Blueprint Medicines average operating margin for 2023 was -235.77%, a 15.44% decline from 2022.
• Blueprint Medicines average operating margin for 2022 was -278.82%, a 68.7% decline from 2021.
• Blueprint Medicines average operating margin for 2021 was -165.28%, a 33.7% increase from 2020.

Operating margin can be defined as operating margin measurement of what proportion of a company's revenue is left over after paying for variable costs of production such as wages, raw materials, etc.