• Ionis Pharmaceuticals average net profit margin for 2023 was -54.58%, a 351.07% decline from 2022.
• Ionis Pharmaceuticals average net profit margin for 2022 was -12.1%, a 80.27% increase from 2021.
• Ionis Pharmaceuticals average net profit margin for 2021 was -61.32%, a 960.9% decline from 2020.

Net profit margin can be defined as net Income as a portion of total sales revenue.