• Ionis Pharmaceuticals average ebitda margin for 2023 was -70.53%, a 491.69% decline from 2022.
• Ionis Pharmaceuticals average ebitda margin for 2022 was -11.92%, a 43.4% increase from 2021.
• Ionis Pharmaceuticals average ebitda margin for 2021 was -21.06%, a 389.68% decline from 2020.

Ebitda margin can be defined as earnings before interest, taxes, depreciation and amortization as a portion of total revenue.