• Ionis Pharmaceuticals average pre-tax profit margin for 2023 was -50.28%, a 335.7% decline from 2022.
• Ionis Pharmaceuticals average pre-tax profit margin for 2022 was -11.54%, a 54.08% increase from 2021.
• Ionis Pharmaceuticals average pre-tax profit margin for 2021 was -25.13%, a 488.41% decline from 2020.

Pre-tax profit margin can be defined as earnings before taxes as a portion of total revenue.