• Ionis Pharmaceuticals average operating margin for 2023 was -72.66%, a 324.66% decline from 2022.
• Ionis Pharmaceuticals average operating margin for 2022 was -17.11%, a 35.85% increase from 2021.
• Ionis Pharmaceuticals average operating margin for 2021 was -26.67%, a 555.9% decline from 2020.

Operating margin can be defined as operating margin measurement of what proportion of a company's revenue is left over after paying for variable costs of production such as wages, raw materials, etc.