• Ionis Pharmaceuticals average return on tangible equity for 2023 was -74.97, a 523.71% increase from 2022.
• Ionis Pharmaceuticals average return on tangible equity for 2022 was -12.02, a 77.3% increase from 2021.
• Ionis Pharmaceuticals average return on tangible equity for 2021 was -52.95, a 2061.22% decline from 2020.

Return on tangible equity can be defined as the amount of net income returned as a percentage of shareholders equity, after subtracting intangible assets, goodwill and preferred equity.